A case of late-onset MELAS.
نویسندگان
چکیده
We describe a 60-year-old man with MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) and discuss the mitochondrial DNA point mutation 3243. A diagnosis of MELAS should be considered in the appropriate clinical setting at any age.
منابع مشابه
Case report: 5 year follow-up of adult late-onset mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS)
Mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS) is a multisystem mitochondrial disorder that typically presents in childhood. We describe the follow-up of a patient who was diagnosed with late-onset MELAS at the age of 49. Her clinical course includes sensorineural hearing loss, seizures, and multiple episodes of stroke-like metabolic crises. Molecular genetic ...
متن کاملLate-onset mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS), defining symptomology
With interest we read Finsterer et al.'s response [1] to our manuscript ‘Case Report: 5 Year Follow-Up of Adult Late-OnsetMitochondrial Encephalomyopathy with Lactic Acid and Stroke-Like Episodes (MELAS)’ [2]. We have the following responses: Regarding the lack of theMRIfigure, theMRIwas performed at an outside hospital. As a result an MRI figure was not available despite efforts to the contrar...
متن کاملA Mitochondrial Disorder in a Middle Age Iranian Patient: Report of a Rare Case
Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by W...
متن کاملPOLG1 mutations and stroke like episodes: a distinct clinical entity rather than an atypical MELAS syndrome
BACKGROUND POLG1 mutations have been associated with MELAS-like phenotypes. However given several clinical differences it is unknown whether POLG1 mutations are possible causes of MELAS or give raise to a distinct clinical and genetic entity, named POLG1-associated encephalopathy. CASE PRESENTATION We describe a 74 years old man carrying POLG1 mutations presenting with strokes, myopathy and r...
متن کاملAdult-onset MELAS presenting as herpes encephalitis.
OBJECTIVE To report an unusual presentation of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) manifested in late life with a clinical picture of herpes simplex encephalitis. DESIGN Case report. SETTING Clinical neurology department in a tertiary care hospital. CASE DESCRIPTION A 55-year-old woman developed aphasia and delirium during ophthalmic herpes z...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Archives of neurology
دوره 55 5 شماره
صفحات -
تاریخ انتشار 1998